Rat CGRP-(8-37)
CAS No. 129121-73-9
Rat CGRP-(8-37) ( )
Catalog No. M30022 CAS No. 129121-73-9
CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor,It is a highly selective CGRP receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameRat CGRP-(8-37)
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NoteResearch use only, not for human use.
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Brief DescriptionCGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor,It is a highly selective CGRP receptor antagonist.
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DescriptionCGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor,It is a highly selective CGRP receptor antagonist.(In Vitro):CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor.(In Vivo):CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels.
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Synonyms
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PathwayOthers
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TargetOther Targets
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RecptorCGRP receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number129121-73-9
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Formula Weight3127.5
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Molecular FormulaC138H224N42O41
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Purity>98% (HPLC)
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SolubilityH2O : 50 mg/mL (15.99 mM; Need ultrasonic)
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SMILES——
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75.
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