Rat CGRP-(8-37)

CAS No. 129121-73-9

Rat CGRP-(8-37) ( )

Catalog No. M30022 CAS No. 129121-73-9

CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor,It is a highly selective CGRP receptor antagonist.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Rat CGRP-(8-37)
  • Note
    Research use only, not for human use.
  • Brief Description
    CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor,It is a highly selective CGRP receptor antagonist.
  • Description
    CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor,It is a highly selective CGRP receptor antagonist.(In Vitro):CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor.(In Vivo):CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels.
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CGRP receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    129121-73-9
  • Formula Weight
    3127.5
  • Molecular Formula
    C138H224N42O41
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : 50 mg/mL (15.99 mM; Need ultrasonic)
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75.
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